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Technician in a blue cleanroom suit operating a SKAN isolator machine using glove ports in a sterile environment.
Transfer systems

mat

The smallest isolator for fast material transfers

Transfer type
Material
Customization level
Modular configuration
mat at a glance

Efficient surface decontamination for materials

  • Maximum safety

    Fully automated processes reduce manual interventions and associated risks

  • Regulatory compliance

    Complies with Annex 1 and all relevant GMP requirements

  • Efficient transfers

    Short transfer paths and times thanks to close proximity to the filling line

  • Compact design

    Only 1.5 m² footprint for easy integration, even in confined production areas

  • Independent operation

    Standalone solution without external HVAC connection thanks to the nanox catalyst

  • Flexible integration

    Compatible with a wide range of materials, container sizes, and production layouts

  • Easy handling

    Floor-level loading solutions and a large glass door for simple operation

  • Individual configuration

    Modular design with numerous shelving solutions and options

Application

Safe transfer of materials and containers into isolator filling lines

  • Filling process pictogram.

    For the preparation of filling processes

    Decontamination and transfer of tools, consumables, and other items required for the aseptic or aseptic-toxic filling operations.

  • H2O2 vial pictogram.

    For the decontamination of heat-sensitive materials

    Decontamination using hydrogen peroxide (H₂O₂) for heat-sensitive materials that cannot be autoclaved, without compromising product quality.

Technician in a blue cleanroom suit working with a large stainless steel transfer port in a sterile laboratory environment.
Process

Efficient transfer from Grade C or Grade D into the Grade A working chamber

  • 1

    Loading

    Materials are loaded into the mat isolator, which is typically positioned close to a filling line in a Grade C or D cleanroom.

  • 2

    Decontamination

    Fully automated cycle using H₂O₂ via skanfog micro-nebulization technology. Efficient process within 30–45 minutes, including leak testing.

  • 3

    Transfer out

    After validated decontamination, transfer via Rapid Transfer Port (RTP) containers. The materials are then introduced into the filling line.

  • 4

    H₂O₂ neutralization

    The nanox catalyst fully decomposes H₂O₂ after decontamination. No HVAC connection is required, as the exhaust air can be safely returned directly to the room.

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Product highlights

Efficient, safe, fast – benefits that make a difference in operation

  • Close-up of a circular white transfer port with a yellow gasket, integrated into a brushed stainless steel surface.

    Automated safety

    A high degree of automation and standardized processes minimize risks in the transfer process and simplify risk assessment.

  • SKANFOG technology nozzle for USP applications.

    Time efficiency

    Cycle times of only 30–45 minutes (for empty chambers, without RTPs) accelerate material flow and increase overall production efficiency.

  • Flexible material transfer isolator for USP applications.

    Operational flexibility

    The process can be adapted to different transfer types, materials, and monitoring requirements without compromising product integrity.

Regulatory requirements

Standardized processes for regulatory-compliant transfers

  • Annex 1-compliant

    Supports microbiological and particulate monitoring in accordance with Annex 1.

  • GMP standards

    Enables GMP-compliant transfers according to EU GMP Grade A (ISO 5).

  • Validation-friendly

    Automated cycles and SOP-based operation reduce validation effort.

MAT material transfer by SKAN: Person in full cleanroom attire handling a cylindrical stainless steel machine component in a laboratory setting.
MAT by SKAN.
MAT by SKAN.

Technical specifications

  • Footprint

    Approx. 1.5 m² (approx. 16 ft²)

  • Weight

    Approx. 800 kg

  • Working chamber

    EU-GMP Grade A (ISO 5)

  • Decontamination

    > 6-log decontamination via skanfog H₂O₂ micro-nebulization

  • Airflow

    Unidirectional, without recirculation

  • Exhaust air

    Directly into the room thanks to SKAN nanox catalyst for rapid decomposition of hydrogen peroxide after decontamination (single-pass reduction of H₂O₂ to < 0.1 ppm)

  • RTP for solids

    Up to size 350

  • AT-Port

    For aseptic liquid transfers

  • Glove test device

    With position control

  • Shelving installation

    Available on request

  • Room monitoring

    H₂O₂ TLV sensor

  • Chamber monitoring

    H₂O₂ sensors

  • Microbial and particulate monitoring

    In accordance with Annex 1

  • Control

    PLC-based system; Siemens or Allen Bradley

  • User interface

    18.5” HMI (customizable)

  • SCADA

    System for monitoring and control, GMP-compliant and 21 CFR Part 11-ready

FAQs

  • mat provides validated decontamination and standardized cycles, minimizing the risk of manual interventions. This supports compliance with the tightened Annex 1 requirements for Contamination Control Strategy (CCS) and aseptic material transfer.

  • Unlike conventional airlocks, mat is fully isolated and operates with automated H₂O₂ cycles. This makes decontamination reproducible, faster, and safer with significantly fewer manual interventions.

  • By reducing transfer paths and times and accelerating decontamination, filling line downtime is reduced. In many cases, mat shortens the material preparation process from several hours to less than one hour, a measurable efficiency gain in routine operation.

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