{"id":54602,"date":"2026-05-04T10:55:29","date_gmt":"2026-05-04T08:55:29","guid":{"rendered":"https:\/\/skan.clients.ideeal.ch\/?post_type=expertise&#038;p=54602"},"modified":"2026-05-04T15:38:20","modified_gmt":"2026-05-04T13:38:20","slug":"behind-the-scenes-of-the-work-in-a-tox-4-lab-at-solvias-ag","status":"publish","type":"expertise","link":"https:\/\/skan.com\/en\/expertise\/lab-cleanroom\/case-story\/solvias-ag","title":{"rendered":"Behind the scenes of the work in a TOX 4 Lab at Solvias AG"},"content":{"rendered":"\r\n        \r\n        \r\n            <section  class=\"section-post-hero\">\r\n            <div class=\"container\">\r\n                <div class=\"section-post-hero-grid\">\r\n                    <div class=\"section-post-hero-media\">\r\n                        <div class=\"entry-media\">\r\n                            \r\n                                <figure class=\"\">\r\n                                                                            <img loading=\"lazy\" decoding=\"async\" width=\"1767\" height=\"2560\" src=\"https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0885-scaled.jpg\" class=\"attachment-full size-full\" alt=\"left side view of the pure2 isolator\" srcset=\"https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0885-scaled.jpg 1767w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0885-207x300.jpg 207w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0885-707x1024.jpg 707w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0885-768x1113.jpg 768w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0885-1060x1536.jpg 1060w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0885-1414x2048.jpg 1414w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0885-290x420.jpg 290w\" sizes=\"auto, (max-width: 1767px) 100vw, 1767px\" \/>                                                                    <\/figure>\r\n                        <\/div>\r\n                    <\/div>\r\n                    <div class=\"section-post-hero-text\">\r\n                                                <div class=\"limiter\">\r\n                                                            <h1>Behind the scenes of the work in a TOX 4 Lab at Solvias AG<\/h1>\r\n                                                                                    <a class=\"link bottom anchor-link\" href=\"#nextSection\" role=\"button\">\r\n                                <span class=\"icon\"><span><span aria-hidden=\"true\"><\/span><\/span><\/span>\r\n                                <span class=\"text\">Learn more<\/span>\r\n                            <\/a>\r\n                        <\/div>\r\n                    <\/div>\r\n                <\/div>\r\n            <\/div>\r\n        <\/section>\r\n        <div aria-hidden=\"true\" id=\"nextSection\"><\/div>\r\n    \r\n    \r\n\n\n    <section  class=\"section-hotspot-element pt-default pb-default\">\r\n        <div class=\"container\">\r\n                                        <div class=\"entry-grid\">\r\n                                            <div class=\"text any-b0\">\r\n                            <p class=\"h3\">\u201cBring your innovation to its destination\u201d\r\nThis is the guiding principle that Solvias follows every day.<\/p>\r\n                        <\/div>\r\n                                                                <div class=\"text any-b0\">\r\n                            <p>At Solvias, collaboration and innovation go hand in hand, and we had the pleasure of sitting down with their team for an insightful interview. This discussion highlighted the strong partnership between Solvias and SKAN, a collaboration built on trust, expertise, and mutual dedication to advancing safety and precision in pharmaceutical and biotech processes.<\/p>\n                        <\/div>\r\n                                    <\/div>\r\n                                <\/div>\r\n    <\/section>\r\n\n\n\t<!-- section two-columns-->\r\n\t<section id=\"secondSection\" class=\"twocolumns-section flexible pt-default pb-default\">\r\n\t\t<div class=\"container\">\r\n\t\t\t<div class=\"df-row\">\r\n\t\t\t\t\t\t\t\t\t<div class=\"column-text col-lg-6 col-xl-5\" id=\"content\">\r\n\t\t\t\t\t\t<div class=\"content-wrap\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"content-block\">\n\t\t<p>In particular, Solvias shared their experience working on the TOX 4 laboratory project, a state-of-the-art facility designed to handle highly toxic substances safely. The centerpiece of this effort is the pure2 isolator, which has exceeded expectations with its safety features, operational reliability and advanced capabilities like the integration of an ultra-microbalance from Mettler Toledo.<\/p>\n<p>The interview sheds light on the seamless collaboration that made this project a success, as well as the significant steps Solvias is taking to ensure occupational safety while pushing the boundaries of analytical excellence. Read on for insights into this exciting partnership and the solutions that continue to drive innovation at Solvias.<\/p>\n<p>A special thanks to Detlef Gestmann, Philip Schwarz and Charlie Brault\u00a0 for taking the time to share their valuable insights and experiences with us. Your feedback and collaboration are greatly appreciated!<\/p>\n\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"content-block\">\n\t\t<ul class=\"accordion accordion-content\">\n\t\t\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"opener\">First of all, could you describe the company Solvias in your words?<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"slide\">\n\t\t\t\t\t\t\t\t<div class=\"slide-body\">\n\t\t\t\t\t\t\t\t\t<p>Solvias is a world leading CRO\/CDMO headquartered in Switzerland. Our highly trained scientists deliver unrivaled expertise, service, and value to customers in the pharmaceutical and biotech industry. Drawing on a proven 20+ year track record of scientific excellence, we provide cGMP-compliant contract analytical services to help you bring safe and effective therapies to patients faster. Our capabilities range from characterization of biologics, ATMPs and small molecule drugs and method development, release testing and stability services. We also offer one of the largest ligand portfolios for catalytic transformations and a suite of related custom API synthesis and catalysis technology services. Our experts use a phase-appropriate analytical testing approach to help you navigate the regulatory environment. With ready access to our subject matter experts and professional project management Solvias helps bring customers\u2019 innovation to its destination.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"opener\">What is the speciality\/focus about the site in Kaiseraugst?<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"slide\">\n\t\t\t\t\t\t\t\t<div class=\"slide-body\">\n\t\t\t\t\t\t\t\t\t<p>The site offers Comprehensive cGMP analytical services, biopharmaceuticals and small molecules, and drug substance and drug product analysis.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"opener\">What made you decide to partner with SKAN in this project?<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"slide\">\n\t\t\t\t\t\t\t\t<div class=\"slide-body\">\n\t\t\t\t\t\t\t\t\t<p>We have had a good business relationship with SKAN for several years. The expertise, dedication and initiative that SKAN always shows made it easy for us to decide which company we wanted to work with on the project. During a visit to the ILMAC trade fair in Basel in 2023, we had the chance to see the pure2 isolator live for the first time, meet the people behind it and get an idea of the unit.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"opener\">What is the scope of your department?<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"slide\">\n\t\t\t\t\t\t\t\t<div class=\"slide-body\">\n\t\t\t\t\t\t\t\t\t<p>The Department of Health, Safety and Environment (HSE) is involved in this project to ensure the occupational safety of employees and the correct handling of highly toxic (TOX 4) substances with an occupational exposure limit (OEL) below 50 ng\/m3.<br \/>\nOur goal is to enable our employees to handle these highly toxic substances safely. To this end, we have worked with an occupational hygienist to determine which parameters are required for setting up a laboratory that can work with such substances. These included the requirement for an isolator. So, together with our laboratory planners, SKAN and various other companies, we planned the so-called TOX 4 laboratory.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"opener\">How did your process look like before purchasing the pure2?<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"slide\">\n\t\t\t\t\t\t\t\t<div class=\"slide-body\">\n\t\t\t\t\t\t\t\t\t<p>We could only handle compounds with an OEL &gt; 50 ng\/ m3 (Solvias TOX 3)<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"opener\">What made you decide to move your process into an isolator?<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"slide\">\n\t\t\t\t\t\t\t\t<div class=\"slide-body\">\n\t\t\t\t\t\t\t\t\t<p>The EKAS 1871 (guideline for laboratories) + 2nd edition 2021 \u2013 Containment Manual of the ISPE D\/A\/CH Working Group Containment legally requires that if you work with substances below an OEL of 50 ng\/m3, you must work with an isolator.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"opener\">How does the process look like in the pure2?<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"slide\">\n\t\t\t\t\t\t\t\t<div class=\"slide-body\">\n\t\t\t\t\t\t\t\t\t<p>Solid sample handling for the TOX 4 samples is only performed inside the isolator. There, the samples are weighed using an ultra-microbalance, diluted with a solvent (e.g. solvent or water), and later the diluted samples are discharged from the isolator. The diluted samples are then analyzed in the TOX 4 laboratory, e.g. characterized using our HPLC.<\/p>\n<p>The qualified ultra-microbalance can weigh up to 3 mg and provides data up to 7 decimal places.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"opener\">What made you decide, on the pure2 isolator?<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"slide\">\n\t\t\t\t\t\t\t\t<div class=\"slide-body\">\n\t\t\t\t\t\t\t\t\t<p>On the one hand, it fully meets our expectations in terms of the safety of our employees and the processing of the TOX 4 samples. For example, it is very easy to clean, it has a good disposal system (Lugaia System), it is even possible to install an ultra-microbalance that runs stably, and it offers a very good volume flow in the different modes (from standby to emergency operation). In addition, the pure2 has a certificate for cystatic agents (DIN 12980:2017-05).<\/p>\n<div class=\"group\/conversation-turn relative flex w-full min-w-0 flex-col agent-turn\">\n<div class=\"flex-col gap-1 md:gap-3\">\n<div class=\"flex max-w-full flex-col flex-grow\">\n<div class=\"min-h-8 text-message flex w-full flex-col items-end gap-2 whitespace-normal break-words text-start [.text-message+&amp;]:mt-5\" dir=\"auto\" data-message-author-role=\"assistant\" data-message-id=\"eccc374d-3187-42b0-a2c1-0976256c0b12\" data-message-model-slug=\"gpt-4o\">\n<div class=\"flex w-full flex-col gap-1 empty:hidden first:pt-[3px]\">\n<div class=\"markdown prose w-full break-words dark:prose-invert light\">\n<p>All in all, the pure2 is a versatile isolator that not only stands out with its various features but also highlights its wide range of applications.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>Furthermore, we have a very good working relationship with SKAN. We know that we can always rely on prompt and effective support from SKAN.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<li>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a class=\"opener\">What has been your experience so far with the pure2?<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"slide\">\n\t\t\t\t\t\t\t\t<div class=\"slide-body\">\n\t\t\t\t\t\t\t\t\t<p>Since it is our first pure<sup>2<\/sup> isolator, we will gain our first experiences in future projects. But so far, the staff have received training from SKAN for the TOX 4 laboratory and we have had very positive experiences so far. One of the biggest successes is the installation of the ultra-microbalance. It was a very exciting project to see if the balance would remain stable at the high air flow.<\/p>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t<\/li>\n\t\t\t\t\t\t\t\t\t<\/ul>\n\t<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t<aside class=\"column-image col-lg-6 col-offset-xl-1\" id=\"aside\">\r\n\t\t\t\t\t\t<div class=\"gallery-visuals-wrap\">\r\n\t\t\t\t\t\t<div class=\"gallery-visuals\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<!-- slide-->\r\n\t\t\t\t\t\t\t\t\t<div class=\"visual-slide\">\r\n\t\t\t\t\t\t\t\t\t\t<div class=\"visual-holder\" >\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"visual-frame animImageLeft  \">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t<picture>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<source type=\"image\/jpeg\" srcset=\"https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0930-scaled.jpg 375w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0930-scaled.jpg 750w\" sizes=\"100vw \" media=\"(max-width: 767px)\"\/>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<source type=\"image\/jpeg\" srcset=\"https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0930-scaled.jpg 740w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0930-scaled.jpg 1480w\" sizes=\"(min-width: 768px) 50vw, 100vw\"\/>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1920\" height=\"2560\" src=\"https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0930-scaled.jpg\" class=\"attachment-full size-full\" alt=\"pure2 Isolator photographed from the windowside\" srcset=\"https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0930-scaled.jpg 1920w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0930-225x300.jpg 225w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0930-768x1024.jpg 768w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0930-1152x1536.jpg 1152w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0930-1536x2048.jpg 1536w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0930-315x420.jpg 315w\" sizes=\"auto, (max-width: 1920px) 100vw, 1920px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/picture>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t<\/aside>\r\n\t\t\t\t\t\t\t<\/div>\r\n\t\t<\/div>\r\n\t<\/section>\r\n\n\n\t<div  class=\"section content-img-wrap images-mod overflow-hidden pt-default pb-default \">\r\n\t\t<div class=\"container\">\r\n\t\t\t<div class=\"article-wrap content-gallery-wrap\">\r\n                <div class=\"content-gallery-header\">\r\n                                            <h2>Impressions<\/h2>\r\n                                        <div class=\"controls\">\r\n                        <div class=\"arrows\"><\/div>\r\n                    <\/div>\r\n                <\/div>\r\n\t\t\t\t<div class=\"content-gallery\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"slick-slide\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"img-wrap\">\r\n\t\t\t\t\t\t\t\t\t\t<div class=\"vd\">\r\n\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"1920\" src=\"https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0913-scaled.jpg\" class=\"attachment-full size-full\" alt=\"picture of the emplyees in front of the pure2 isolator\" srcset=\"https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0913-scaled.jpg 2560w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0913-300x225.jpg 300w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0913-1024x768.jpg 1024w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0913-768x576.jpg 768w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0913-1536x1152.jpg 1536w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0913-2048x1536.jpg 2048w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0913-357x268.jpg 357w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/>\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t\t<div class=\"vm\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"2560\" height=\"1920\" src=\"https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0913-scaled.jpg\" class=\"attachment-full size-full\" alt=\"picture of the emplyees in front of the pure2 isolator\" srcset=\"https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0913-scaled.jpg 2560w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0913-300x225.jpg 300w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0913-1024x768.jpg 1024w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0913-768x576.jpg 768w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0913-1536x1152.jpg 1536w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0913-2048x1536.jpg 2048w, https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0913-357x268.jpg 357w\" sizes=\"auto, (max-width: 2560px) 100vw, 2560px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"slick-slide\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"img-wrap\">\r\n\t\t\t\t\t\t\t\t\t\t<div class=\"vd\">\r\n\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1920\" height=\"2560\" src=\"https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0897-scaled.jpg\" class=\"attachment-full size-full\" alt=\"Inside view of the left chamber in the pure2 isolator\" srcset=\"https:\/\/skan.com\/wp-content\/uploads\/2026\/05\/IMG_0897-scaled.jpg 1920w, 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